Publications

Partial list of publications using the BCLQ cells and data

These studies all used samples or data from the Quebec Leukemia Cell Bank. The list is updated periodically and is not exhaustive; every title links to its PubMed record.

86publications
43journals
2012–2026years covered
31since 2020

86 publications

2026

1 publication

TP53-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition

Spinella JF, Chagraoui J, Moison C, Boivin I, Carpentier GR, Mayotte N, Béliveau F, Lavallée VP, Hébert J, Sauvageau G

Sci Adv2026;12(20):eaed7122DOI PubMed

2025

7 publications

Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines

Safa-Tahar-Henni S, Páez Martinez K, Gress V, Esparza N, Roques É, Bonnet-Magnaval F, Bilodeau M, Gagné V, Bresson E, Cardin S, El-Hachem N, Iasenza I, Alzial G, Boivin I, Nakamichi N, Soufflet AC, Mirela Pascariu C, Duchaine J, Mathien S, Bonneil É, Eppert K, Marinier A, Sauvageau G, Deblois G, Thibault P, Hébert J, Eaves CJ, Cellot S, Barabé F, Wilhelm BT

Leukemia2025;39(1):29-41DOI PubMed

DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition

Moison C, Mendoza-Sanchez R, Gracias D, Schuetz DA, Spinella JF, Girard S, Thavonekham B, Chagraoui J, Durand A, Fortier S, MacRae T, Bonneil E, Rose Y, Mayotte N, Boivin I, Thibault P, Hébert J, Ruel R, Marinier A, Sauvageau G

EMBO Rep2025;26(11):2836-2854DOI PubMed

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

Kaya F, Bewicke-Copley F, Miettinen JJ, Casado P, Leddy E, Deniz Ö, Lavallée VP, Philippe C, Zheng J, Grebien F, Khan N, Krizsán S, Saad J, Nolin-Lapalme A, Hébert J, Lemieux S, Audemard E, Matthews J, Grantham M, Di Bella D, Wennerberg K, Parsons A, Gribben J, Cavenagh JD, Freeman SD, Bödör C, Sauvageau G, Wang J, Llamas-Sillero P, Cazier JB, Taussig DC, Bonnet D, Cutillas PR, Heckman CA, Fitzgibbon J, Rouault-Pierre K, Rio-Machin A

Leukemia2025;39(6):1526-1531DOI PubMed

High IL1R1 expression predicts poor survival and benefit from stem cell transplant in intermediate-risk acute myeloid leukemia from the Leucegene cohort

Richard-Carpentier G, Béliveau F, Lacoste S, Khakipoor B, Lisi V, Vladovsky M, Marquis M, Spinella JF, Gendron P, Lemieux S, Lavallée VP, Sauvageau G, Hébert J

Biomark Res2025;13(1):133DOI PubMed

IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia

Métois A, Bordeleau ME, Theret L, Hajmirza A, Moujaber O, Spinella JF, Chagraoui J, Mayotte N, Boivin I, Audemard É, Aubert L, Lisi V, Khakipoor B, Farah A, Bonneil É, Robert A, Lippens J, Moraitis A, Béliveau F, Feghaly A, Boucher G, Marcotte R, Gendron P, Thibault P, Lemieux S, Richard-Carpentier G, Lavallée VP, Hébert J, Roux PP, Sauvageau G

Biomark Res2025;13(1):61DOI PubMed

Improved identification of clinically relevant Acute Leukemia subtypes using standardized EuroFlow panels versus non-standardized approach

Terra R, Éthier V, Busque L, Morin-Quintal A, D'Angelo G, Hébert J, Wang X, Lépine G, LeBlanc R, Bergeron J

Cytometry B Clin Cytom2025;108(2):116-127DOI PubMed

Replication of a GWAS signal near HLA-DQA2 with AML using a disease-only cohort and external population-based controls

Laflamme R, Lisi V, Hébert J, Sauvageau G, Lemieux S, Lavallée VP, Lettre G

Blood Neoplasia2025;2(3):100118DOI PubMed

2024

6 publications

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216

Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S

Blood Adv2024;8(1):112-129DOI PubMed

DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

Spinella JF, Chagraoui J, Moison C, Lavallée VP, Boivin I, Gracias D, Lavallée S, Carpentier GR, Beliveau F, Hébert J, Sauvageau G

Leukemia2024;38(3):530-537DOI PubMed

Immunotherapeutic targeting of surfaceome heterogeneity in AML

Bordeleau ME, Audemard É, Métois A, Theret L, Lisi V, Farah A, Spinella JF, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil É, Béliveau F, Pfammatter S, Feghaly A, Boucher G, Gendron P, Thibault P, Barabé F, Lemieux S, Richard-Carpentier G, Hébert J, Lavallée VP, Roux PP, Sauvageau G

Cell Rep2024;43(6):114260DOI PubMed

Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials

H Elsayed A, Cao X, Marrero RJ, Nguyen NHK, Wu H, Ni Y, Ribeiro RC, Tobias H, Valk PJ, Béliveau F, Richard-Carpentier G, Hébert J, Zwaan CM, Gamis A, Kolb EA, Aplenc R, Alonzo TA, Meshinchi S, Rubnitz J, Pounds S, Lamba JK

NPJ Precis Oncol2024;8(1):168DOI PubMed

SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

Moison C, Gracias D, Schmitt J, Girard S, Spinella JF, Fortier S, Boivin I, Mendoza-Sanchez R, Thavonekham B, MacRae T, Mayotte N, Bonneil E, Wittman M, Carmichael J, Ruel R, Thibault P, Hébert J, Marinier A, Sauvageau G

Sci Adv2024;10(12):eadl4018DOI PubMed

Unveiling the Complexity of KMT2A Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping

Lacoste SA, Gagnon V, Béliveau F, Lavallée S, Collin V, Hébert J

Cancers (Basel)2024;16(24)DOI PubMed

2023

3 publications

GPRC5C drives branched-chain amino acid metabolism in leukemogenesis

Zhang YW, Velasco-Hernandez T, Mess J, Lalioti ME, Romero-Mulero MC, Obier N, Karantzelis N, Rettkowski J, Schönberger K, Karabacz N, Jäcklein K, Morishima T, Trincado JL, Romecin P, Martinez A, Takizawa H, Shoumariyeh K, Renders S, Zeiser R, Pahl HL, Béliveau F, Hébert J, Lehnertz B, Sauvageau G, Menendez P, Cabezas-Wallscheid N

Blood Adv2023;7(24):7525-7538DOI PubMed

Heterogeneity in leukemia cells that escape drug-induced senescence-like state

Miller D, Kerkhofs K, Abbas-Aghababazadeh F, Madahar SS, Minden MD, Hébert J, Haibe-Kains B, Bayfield MA, Benchimol S

Cell Death Dis2023;14(8):503DOI PubMed

Optical Genome Mapping Reveals the Complex Genetic Landscape of Myeloma

Giguère A, Raymond-Bouchard I, Collin V, Claveau JS, Hébert J, LeBlanc R

Cancers (Basel)2023;15(19)DOI PubMed

2022

6 publications

CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia

He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB, Pabst C

EMBO Mol Med2022;14(4):e14990DOI PubMed

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis

Milan T, Celton M, Lagacé K, Roques É, Safa-Tahar-Henni S, Bresson E, Bergeron A, Hebert J, Meshinchi S, Cellot S, Barabé F, Wilhelm BT

Haematologica2022;107(1):86-99DOI PubMed

HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition

Moison C, Spinella JF, Chagraoui J, Lavallée VP, Lehnertz B, Thiollier C, Boivin I, Mayotte N, MacRae T, Marinier A, Hébert J, Sauvageau G

Blood Adv2022;6(16):4793-4806DOI PubMed

Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia

Veiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, Lemieux S, Zúñiga-Pflücker JC, Hébert J, Cohen JP, Hoang T

Front Immunol2022;13:867443DOI PubMed

Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia

Lisi V, Blanchard È, Vladovsky M, Audemard É, Feghaly A, Lemieux S, Hébert J, Sauvageau G, Lavallée VP

Blood Adv2022;6(17):5160-5164DOI PubMed

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia

Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau G

Blood Adv2022;6(2):509-514DOI PubMed

2021

4 publications

Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling

Rys RN, Wever CM, Geoffrion D, Goncalves C, Ghassemian A, Brailovski E, Ryan J, Stoica L, Hébert J, Petrogiannis-Haliotis T, Dmitrienko S, Frenkiel S, Staiger A, Ott G, Steidl C, Scott DW, Sesques P, Del Rincon S, Mann KK, Letai A, Johnson NA

Cancers (Basel)2021;13(5)DOI PubMed

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C

Immunity2021;54(4):737-752.e10DOI PubMed

Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

Mer AS, Heath EM, Madani Tonekaboni SA, Dogan-Artun N, Nair SK, Murison A, Garcia-Prat L, Shlush L, Hurren R, Voisin V, Bader GD, Nislow C, Rantalainen M, Lehmann S, Gower M, Guidos CJ, Lupien M, Dick JE, Minden MD, Schimmer AD, Haibe-Kains B

Nat Commun2021;12(1):1054DOI PubMed

Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients

Reid JC, Golubeva D, Boyd AL, Hollands CG, Henly C, Orlando L, Leber A, Hébert J, Morabito F, Cutrona G, Agnelli L, Gentile M, Ferrarini M, Neri A, Leber B, Bhatia M

Cell Rep2021;34(11):108845DOI PubMed

2020

4 publications

Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia

Pincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laramée L, Couture F, Sinnett D, Gendron P, Hébert J, Oligny L, Rouette A, Tran TH, Wilhelm BT, Bittencourt H, Cellot S

Genes Chromosomes Cancer2020;59(2):125-130DOI PubMed

Genetic characterization of ABT-199 sensitivity in human AML

Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D'Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G

Leukemia2020;34(1):63-74DOI PubMed

High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML

Simon L, Spinella JF, Yao CY, Lavallée VP, Boivin I, Boucher G, Audemard E, Bordeleau ME, Lemieux S, Hébert J, Sauvageau G

Blood2020;135(21):1882-1886DOI PubMed

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM

NAR Cancer2020;2(3):zcaa019DOI PubMed

2019

7 publications

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition

Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G

Blood Adv2019;3(4):552-563DOI PubMed

Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting

Tremblay G, Rousseau B, Marquis M, Beaubois C, Sauvageau G, Hébert J

Appl Health Econ Health Policy2019;17(6):827-839DOI PubMed

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg JB, Barabé F, Pabst C

Blood2019;134(3):263-276DOI PubMed

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad É, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot S

Blood Adv2019;3(21):3307-3321DOI PubMed

IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome

Mourad S, Bilodeau M, Roussy M, Laramée L, Boulianne L, Rouette A, Jouan L, Gendron P, Duval M, Teira P, Hébert J, Bittencourt H, Pastore Y, Landry JR, Cellot S

Front Oncol2019;9:772DOI PubMed

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G

Cancer Cell2019;36(1):84-99.e8DOI PubMed

The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

Angenendt L, Bormann E, Pabst C, Alla V, Görlich D, Braun L, Dohlich K, Schwöppe C, Bohlander SK, Arteaga MF, Wethmar K, Hartmann W, Angenendt A, Kessler T, Mesters RM, Stelljes M, Rothenberg-Thurley M, Spiekermann K, Hébert J, Sauvageau G, Valk PJM, Löwenberg B, Serve H, Müller-Tidow C, Lenz G, Wörmann BJ, Sauerland MC, Hiddemann W, Berdel WE, Krug U, Metzeler KH, Mikesch JH, Herold T, Schliemann C

Leukemia2019;33(12):2830-2841DOI PubMed

2018

6 publications

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hébert J, Dellaire G, Côté JF, Richard S, Orthwein A, Drobetsky E, Möröy T

Nat Commun2018;9(1):1418DOI PubMed

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

Marquis M, Beaubois C, Lavallée VP, Abrahamowicz M, Danieli C, Lemieux S, Ahmad I, Wei A, Ting SB, Fleming S, Schwarer A, Grimwade D, Grey W, Hills RK, Vyas P, Russell N, Sauvageau G, Hébert J

Blood Cancer J2018;8(8):68DOI PubMed

Noncoding regions are the main source of targetable tumor-specific antigens

Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C

Sci Transl Med2018;10(470)DOI PubMed

NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy

Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S

Genes Chromosomes Cancer2018;57(6):311-319DOI PubMed

The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples

Wever CM, Geoffrion D, Grande BM, Yu S, Alcaide M, Lemaire M, Riazalhosseini Y, Hébert J, Gavino C, Vinh DC, Petrogiannis-Haliotis T, Dmitrienko S, Mann KK, Morin RD, Johnson NA

Leuk Lymphoma2018;59(9):2159-2174DOI PubMed

Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin

Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau G

Leukemia2018;32(6):1349-1357DOI PubMed

2017

7 publications

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens

Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G

Blood Cancer J2017;7(2):e529DOI PubMed

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity

Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau G

Clin Cancer Res2017;23(22):6969-6981DOI PubMed

H3(K27M/I) mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

Lehnertz B, Zhang YW, Boivin I, Mayotte N, Tomellini E, Chagraoui J, Lavallée VP, Hébert J, Sauvageau G

Blood2017;130(20):2204-2214DOI PubMed

Identification of novel biomarkers for MLL-translocated acute myeloid leukemia

Lagacé K, Barabé F, Hébert J, Cellot S, Wilhelm BT

Exp Hematol2017;56:58-63DOI PubMed

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets

Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G

Nucleic Acids Res2017;45(13):e122DOI PubMed

Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target

Barabé F, Gil L, Celton M, Bergeron A, Lamontagne V, Roques É, Lagacé K, Forest A, Johnson R, Pécheux L, Simard J, Pelloux J, Bellemare-Pelletier A, Gagnon E, Hébert J, Cellot S, Wilhelm BT

Leukemia2017;31(5):1166-1176DOI PubMed

S100A9 induces differentiation of acute myeloid leukemia cells through TLR4

Laouedj M, Tardif MR, Gil L, Raquil MA, Lachhab A, Pelletier M, Tessier PA, Barabé F

Blood2017;129(14):1980-1990DOI PubMed

2016

9 publications

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G

Blood2016;127(24):3054-61DOI PubMed

Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts

Baruah PS, Beauchemin M, Hébert J, Bertrand R

PLoS One2016;11(7):e0159091DOI PubMed

Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers

Rouette A, Trofimov A, Haberl D, Boucher G, Lavallée VP, D'Angelo G, Hébert J, Sauvageau G, Lemieux S, Perreault C

Sci Rep2016;6:34019DOI PubMed

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F

Blood2016;127(16):2018-27DOI PubMed

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T

J Clin Invest2016;126(12):4569-4584DOI PubMed

Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J, Sauvageau G

Leukemia2016;30(7):1621-4DOI PubMed

RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, Sauvageau G, Hébert J

Blood2016;127(20):2498-501DOI PubMed

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

Maiga A, Lemieux S, Pabst C, Lavallée VP, Bouvier M, Sauvageau G, Hébert J

Blood Cancer J2016;6(6):e431DOI PubMed

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, Pflumio F, Hébert J, Couture JF, Perkins TJ, Ge K, Dilworth FJ, Brand M

Genes Dev2016;30(5):508-21DOI PubMed

2015

3 publications

Disclosure of incidental findings in cancer genomic research: investigators' perceptions on obligations and barriers

Kleiderman E, Avard D, Besso A, Ali-Khan S, Sauvageau G, Hébert J

Clin Genet2015;88(4):320-6DOI PubMed

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations

Lavallée VP, Gendron P, Lemieux S, D'Angelo G, Hébert J, Sauvageau G

Blood2015;125(1):140-3DOI PubMed

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G

Nat Genet2015;47(9):1030-7DOI PubMed

2014

9 publications

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia

Celton M, Forest A, Gosse G, Lemieux S, Hebert J, Sauvageau G, Wilhelm BT

Leukemia2014;28(8):1617-26DOI PubMed

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance

Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA

Blood2014;123(11):1720-8DOI PubMed

Feasibility study: phosphospecific flow cytometry enabling rapid functional analysis of bone marrow samples from patients with multiple myeloma

Simard C, Cloutier M, Néron S

Cytometry B Clin Cytom2014;86(2):139-44DOI PubMed

Identification of small molecules that support human leukemia stem cell activity ex vivo

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G

Nat Methods2014;11(4):436-42DOI PubMed

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T

PLoS Genet2014;10(12):e1004768DOI PubMed

The methyltransferase G9a regulates HoxA9-dependent transcription in AML

Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM

Genes Dev2014;28(4):317-27DOI PubMed

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL

Nature2014;511(7507):90-3DOI PubMed

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, Barbour H, Corbeil L, Hébert J, Drobetsky E, Masson JY, Di Noia JM, Affar el B

Proc Natl Acad Sci U S A2014;111(1):285-90DOI PubMed

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G

Blood2014;124(15):2362-9DOI PubMed

2013

8 publications

eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition

Osborne MJ, Volpon L, Kornblatt JA, Culjkovic-Kraljacic B, Baguet A, Borden KL

Proc Natl Acad Sci U S A2013;110(10):3877-82DOI PubMed

Identification of a novel fusion gene involving RUNX1 and the antisense strand of SV2B in a BCR-ABL1-positive acute leukemia

Giguère A, Hébert J

Genes Chromosomes Cancer2013;52(12):1114-22DOI PubMed

Monitoring Response and Resistance to the Novel Arsenical Darinaparsin in an AML Patient

Nielsen TH, Johnson N, Garnier N, Kwan S, Yao L, Cocolakis E, Hébert J, Morgan RA, Paquet E, Callahan KP, Jordan CT, Assouline S, Miller WH Jr, Mann KK

Front Pharmacol2013;4:9DOI PubMed