Publications

• DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition. Moison C, Mendoza-Sanchez R, Gracias D, Schuetz DA, Spinella JF, Girard S, Thavonekham B, Chagraoui J, Durand A, Fortier S, MacRae T, Bonneil E, Rose Y, Mayotte N, Boivin I, Thibault P, Hébert J, Ruel R, Marinier A, Sauvageau G. EMBO Rep. 2025 Apr 28. doi: 10.1038/s44319-025-00448-y. Epub ahead of print. PMID: 40295725.
• IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia. Métois A, Bordeleau ME, Theret L, Hajmirza A, Moujaber O, Spinella JF, Chagraoui J, Mayotte N, Boivin I, Audemard É, Aubert L, Lisi V, Khakipoor B, Farah A, Bonneil É, Robert A, Lippens J, Moraitis A, Béliveau F, Feghaly A, Boucher G, Marcotte R, Gendron P, Thibault P, Lemieux S, Richard-Carpentier G, Lavallée VP, Hébert J, Roux PP, Sauvageau G. Biomark Res. 2025 Apr 14;13(1):61. doi: 10.1186/s40364-025-00769-z. PMID: 40229904.
• DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes. Kaya F, Bewicke-Copley F, Miettinen JJ, Casado P, Leddy E, Deniz Ö, Lavallée VP, Philippe C, Zheng J, Grebien F, Khan N, Krizsán S, Saad J, Nolin-Lapalme A, Hébert J, Lemieux S, Audemard E, Matthews J, Grantham M, Di Bella D, Wennerberg K, Parsons A, Gribben J, Cavenagh JD, Freeman SD, Bödör C, Sauvageau G, Wang J, Llamas-Sillero P, Cazier JB, Taussig DC, Bonnet D, Cutillas PR, Heckman CA, Fitzgibbon J, Rouault-Pierre K, Rio-Machin A. Leukemia. 2025 Apr 9. doi: 10.1038/s41375-025-02593-8. Epub ahead of print. PMID: 40204893.
• Unveiling the Complexity of KMT2A Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping. Lacoste SA, Gagnon V, Béliveau F, Lavallée S, Collin V, Hébert J. Cancers (Basel). 2024 Dec 14;16(24):4171. doi: 10.3390/cancers16244171. PMID: 39766070.
• Improved identification of clinically relevant Acute Leukemia subtypes using standardized EuroFlow panels versus non-standardized approach. Terra R, Éthier V, Busque L, Morin-Quintal A, D’Angelo G, Hébert J, Wang X, Lépine G, LeBlanc R, Bergeron J. Cytometry B Clin Cytom. 2024 Nov 13. doi: 10.1002/cyto.b.22213. Epub ahead of print. PMID: 39538364.
• Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines. Safa-Tahar-Henni S, Páez Martinez K, Gress V, Esparza N, Roques É, Bonnet-Magnaval F, Bilodeau M, Gagné V, Bresson E, Cardin S, El-Hachem N, Iasenza I, Alzial G, Boivin I, Nakamichi N, Soufflet AC, Mirela Pascariu C, Duchaine J, Mathien S, Bonneil É, Eppert K, Marinier A, Sauvageau G, Deblois G, Thibault P, Hébert J, Eaves CJ, Cellot S, Barabé F, Wilhelm BT. Leukemia. 2024 Oct 29. doi: 10.1038/s41375-024-02400-w. Epub ahead of print. PMID: 39472547.
• Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials. H Elsayed A, Cao X, Marrero RJ, Nguyen NHK, Wu H, Ni Y, Ribeiro RC, Tobias H, Valk PJ, Béliveau F, Richard-Carpentier G, Hébert J, Zwaan CM, Gamis A, Kolb EA, Aplenc R, Alonzo TA, Meshinchi S, Rubnitz J, Pounds S, Lamba JK. NPJ Precis Oncol. 2024 Aug 1;8(1):168. doi: 10.1038/s41698-024-00643-5. PMID: 39090192.
• Immunotherapeutic targeting of surfaceome heterogeneity in AML. Bordeleau ME, Audemard É, Métois A, Theret L, Lisi V, Farah A, Spinella JF, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil É, Béliveau F, Pfammatter S, Feghaly A, Boucher G, Gendron P, Thibault P, Barabé F, Lemieux S, Richard-Carpentier G, Hébert J, Lavallée VP, Roux PP, Sauvageau G. Cell Rep. 2024 Jun 4;43(6):114260. doi: 10.1016/j.celrep.2024.114260. PMID: 38838225.
• SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia. Moison C, Gracias D, Schmitt J, Girard S, Spinella JF, Fortier S, Boivin I, Mendoza-Sanchez R, Thavonekham B, MacRae T, Mayotte N, Bonneil E, Wittman M, Carmichael J, Ruel R, Thibault P, Hébert J, Marinier A, Sauvageau G. Sci Adv. 2024 Mar 22;10(12):eadl4018. doi: 10.1126/sciadv.adl4018. PMID: 38517966.
• DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML. Spinella JF, Chagraoui J, Moison C, Lavallée VP, Boivin I, Gracias D, Lavallée S, Carpentier GR, Beliveau F, Hébert J, Sauvageau G. Leukemia. 2023 Dec 15. doi: 10.1038/s41375-023-02107-4. PMID: 38102204.
• Optical Genome Mapping Reveals the Complex Genetic Landscape of Myeloma. Giguère A, Raymond-Bouchard I, Collin V, Claveau JS, Hébert J, LeBlanc R.  Cancers (Basel). 2023 Sep 22;15(19):4687. doi: 10.3390/cancers15194687. PMID: 37835381.
• CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216. Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S. Blood Adv. 2023 Sep 20:bloodadvances.2022008899. doi: 10.1182/bloodadvances.2022008899. PMID: 37729615.
• GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis. Zhang YW, Velasco-Hernandez T, Mess J, Lalioti ME, Romero-Mulero MC, Obier N, Karantzelis N, Rettkowski J, Schönberger K, Karabacz N, Jäcklein K, Morishima T, Trincado JL, Romecin P, Martinez-Moreno A, Takizawa H, Shoumariyeh K, Renders S, Zeiser R, Pahl HL, Béliveau F, Hébert J, Lehnertz B, Sauvageau G, Menendez P, Cabezas-Wallscheid N. Blood Adv. 2023 Aug 28:bloodadvances.2023010460. doi: 10.1182/bloodadvances.2023010460. PMID: 37639313.
• Heterogeneity in leukemia cells that escape drug-induced senescence-like state. Miller D, Kerkhofs K, Abbas-Aghababazadeh F, Madahar SS, Minden MD, Hébert J, Haibe-Kains B, Bayfield MA, Benchimol S. Cell Death Dis. 2023 Aug 5;14(8):503. doi: 10.1038/s41419-023-06015-4. PMID: 37543610.
• Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia. Lisi V, Blanchard È, Vladovsky M, Audemard E, Ferghaly A, Lemieux S, Hebert J, Sauvageau G, Lavallee VP. Blood Adv. 2022 Jul 18;. doi: 10.1182/bloodadvances.2022007300. PubMed PMID: 35849707.
• HMGA2 expression defines a subset of AML with immature transcriptional signature and vulnerability to G2/M inhibition.Moison C, Spinella JF, Chagraoui J, Lavallee VP, Lehnertz B, Thiollier C, Boivin I, Mayotte N, MacRae T, Marinier A, Hébert J, Sauvageau G.Blood Adv. 2022 Jul 7;. doi: 10.1182/bloodadvances.2021005828. PubMed PMID: 35797243
• Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.Veiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, Lemieux S, Zúñiga-Pflücker JC, Hébert J, Cohen JP, Hoang T.  Front Immunol. 2022 Mar 24;13:867443. doi: 10.3389/fimmu.2022.867443. eCollection 2022. PMID: 35401501
•  CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia. He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB, Pabst C. EMBO Mol Med. 2022 Mar 7;:e14990. doi: 10.15252/emmm.202114990. PubMed PMID: 35253392.
• Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia. Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau G. Blood Adv. 2021 Nov 3:bloodadvances.2021006047. doi: 10.1182/bloodadvances.2021006047. PMID: 34731885.
• Reid JC, Golubeva D, Boyd AL, Hollands CG, Henly C, Orlando L, Leber A, Hébert J, Morabito F, Cutrona G, Agnelli L, Gentile M, Ferrarini M, Neri A, Leber B, Bhatia M. Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients. Cell Rep. 2021 Mar 16;34(11):108845. doi: 10.1016/j.celrep.2021.108845. PMID: 33730576.
• Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C. Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.Immunity. 2021 Mar 15:S1074-7613(21)00087-X. doi: 10.1016/j.immuni.2021.03.001. PMID: 33740418.
• Rys RN, Wever CM, Geoffrion D, Goncalves C, Ghassemian A, Brailovski E, Ryan J, Stoica L, Hébert J, Petrogiannis-Haliotis T, Dmitrienko S, Frenkiel S, Staiger A, Ott G, Steidl C, Scott DW, Sesques P, Del Rincon S, Mann KK, Letai A, Johnson NA. Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling. Cancers (Basel). 2021 Feb 28;13(5):1002. doi: 10.3390/cancers13051002. PMID: 33670870.
• Mer, A.S., Heath, E.M., Madani Tonekaboni, S.A. et al. Biological and therapeutic implications of a unique subtype of NPM1 mutated AML. Nat Commun 12, 1054 (2021). https://doi.org/10.1038/s41467-021-21233-0. PMID: 33594052.
• Milan T, Celton M, Lagacé K, Roques É, Safa-Tahar-Henni S, Bresson E, Bergeron A, Hebert J, Meshinchi S, Cellot S, Barabé F, Wilhelm BT. Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis. Haematologica. 2020 Dec 30;Online ahead of print. doi: 10.3324/haematol.2020.271619. PMID: 33375773.
• Safavi S, Larouche A, Zahn A, Patenaude AM, Domanska D, Dionne K, Rognes T, Dingler F, Kang SK, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM.  The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. NAR Cancer. 2020 Aug 27;2(3):zcaa019. doi: 10.1093/narcan/zcaa019. eCollection 2020 Sep. PMID: 33554121.
• Simon L, Spinella JF, Yao CY, Lavallée VP, Boivin I, Boucher G, Audemard E, Bordeleau ME, Lemieux S, Hebert J, Sauvageau G. High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.Blood. 2020 Feb 13. pii: blood.2019003357. doi: 10.1182/blood.2019003357. PMID: 32315381.
• Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad É, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot S. Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities. Blood Adv. 2019 Nov 12;3(21):3307-3321. doi: 10.1182/bloodadvances.2019030981. PubMed PMID: 31698461.
• Pincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laramée L, Couture F, Sinnett D, Gendron P, Hébert J, Oligny L, Rouette A, Tran TH, Wilhelm BT, Bittencourt H, Cellot S. Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2020 Feb;59(2):125-130. doi: 10.1002/gcc.22808. Epub 2019 Oct 4. PubMed PMID: 31515871.
• Mourad S, Bilodeau M, Roussy M, Laramée L, Boulianne L, Rouette A, Jouan L, Gendron P, Duval M, Teira P, Hébert J, Bittencourt H, Pastore Y, Landry JR, Cellot S. IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome. Front Oncol. 2019;9:772. doi: 10.3389/fonc.2019.00772. eCollection 2019. PubMed PMID: 31475115.
• Tremblay G, Rousseau B, Marquis M, Beaubois C, Sauvageau G, Hébert J. Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting. Appl Health Econ Health Policy. 2019 Aug 7;. doi: 10.1007/s40258-019-00503-5. PubMed PMID: 31392669.
• Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D’Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G. Genetic characterization of ABT-199 sensitivity in human AML. Leukemia. 2019 Jul 12;. doi: 10.1038/s41375-019-0485-x. PubMed PMID: 31300747.
• Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia. Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003. PubMed PMID: 31287994.
• Angenendt L, Bormann E, Pabst C, Alla V, Görlich D, Braun L, Dohlich K, Schwöppe C, Bohlander SK, Arteaga MF, Wethmar K, Hartmann W, Angenendt A, Kessler T, Mesters RM, Stelljes M, Rothenberg-Thurley M, Spiekermann K, Hébert J, Sauvageau G, Valk PJM, Löwenberg B, Serve H, Müller-Tidow C, Lenz G, Wörmann BJ, Sauerland MC, Hiddemann W, Berdel WE, Krug U, Metzeler KH, Mikesch JH, Herold T, Schliemann C.The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia. Leukemia. 2019 Jun 10;. doi: 10.1038/s41375-019-0505-x. PubMed PMID: 31182782.
• Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg J, Barabé F, Pabst C. Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.Blood. 2019 May 10. pii: blood.2018862383. doi: 10.1182/blood.2018862383. PMID: 31076446.
• Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G. Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition. Blood Adv. 2019 Feb 26;3(4):552-563. doi: 10.1182/bloodadvances.2018028480. PubMed PMID: 30782614.
• Laumont CM,Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C. Noncoding regions are the main source of targetable tumor-specific antigens. Sci Transl Med. 2018 Dec 5;10(470). pii: eaau5516. doi: 10.1126/scitranslmed.aau5516. PubMed : PMID 30518613.
• Marquis M, Beaubois C, Lavallée VP, Abrahamowicz M, Danieli C, Lemieux S, Ahmad I, Wei A, Ting SB, Fleming S, Schwarer A, Grimwade D, Grey W, Hills RK, Vyas P, Russell N, Sauvageau G, Hébert J. High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia. Blood Cancer J. 2018 Jul 19;8(8):68. doi: 10.1038/s41408-018-0103-6. PubMed PMID: 30061630.
• Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hebert J, Dellaire G, Cote JF, Richard S, Orthwein A, Drobetsky E, Moroy T. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nature communications. 2018;9(1):1418. doi: 10.1038/s41467-018-03817-5. PubMed PMID: 29651020.
• Lavallee VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GE, Hebert J, Sauvageau G. Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin. Leukemia. 2018. doi: 10.1038/s41375-018-0069-1. PubMed PMID: 29550835.
•  Roussy M, Bilodeau M, Jouan L, Tibout P, Laramee L, Lemyre E, Cardin S, Sauvageau C, Couture F, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hebert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S. NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy. Genes, chromosomes & cancer. 2018. doi: 10.1002/gcc.22532. PubMed PMID: 29427526. 
• Wever CM, Geoffrion D, Grande BM, Yu S, Alcaide M, Lemaire M, Riazalhosseini Y, Hebert J, Gavino C, Vinh DC, Petrogiannis-Haliotis T, Dmitrienko S, Mann KK, Morin RD, Johnson NA. The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples. Leukemia & lymphoma. 2018:1-16. doi: 10.1080/10428194.2017.1413186. PubMed PMID: 29295643. 
• Lemieux S, Sargeant T, Laperriere D, Ismail H, Boucher G, Rozendaal M, Lavallee VP, Ashton-Beaucage D, Wilhelm B, Hebert J, Hilton DJ, Mader S, Sauvageau G. MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. Nucleic acids research. 2017;45(13):e122. doi: 10.1093/nar/gkx338. PubMed PMID: 28472340.
•  Lagace K, Barabe F, Hebert J, Cellot S, Wilhelm BT. Identification of novel biomarkers for MLL-translocated acute myeloid leukemia. Experimental hematology. 2017;56:58-63. doi: 10.1016/j.exphem.2017.08.006. PubMed PMID: 28911906. 
•  Lehnertz B, Zhang YW, Boivin I, Mayotte N, Tomellini E, Chagraoui J, Lavallee VP, Hebert J, Sauvageau G. H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations. Blood. 2017. doi: 10.1182/blood-2017-03-774653. PubMed PMID: 28855157.
•  Simon L, Lavallee VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny YA, Lemieux S, Marinier A, Hebert J, Sauvageau G. Chemogenomic landscape of RUNX1-mutated AML reveals importance of RUNX1 allele dosage in genetics and glucocorticoid sensitivity. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017. doi: 10.1158/1078-0432.CCR-17-1259. PubMed PMID: 28855357. 
• Laouedj M, Tardif MR, Gil L, Raquil MA, Lachhab A, Pelletier M, Tessier PA, Barabe F. S100A9 induces differentiation of acute myeloid leukemia cells through TLR4. Blood. 2017;129(14):1980-90. doi: 10.1182/blood-2016-09-738005. PubMed PMID: 28137827.
• Baccelli I, Krosl J, Boucher G, Boivin I, Lavallee VP, Hebert J, Lemieux S, Marinier A, Sauvageau G. A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens. Blood cancer journal. 2017;7(2):e529. doi: 10.1038/bcj.2017.10. PubMed PMID: 28211886.
• Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hebert J, Sauvageau G, Kwok BH, Roux PP, Hoang T. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells. The Journal of clinical investigation. 2016. doi: 10.1172/JCI86489. PubMed PMID: 27797342.
• Barabe F, Gil L, Celton M, Bergeron A, Lamontagne V, Roques E, Lagace K, Forest A, Johnson R, Pecheux L, Simard J, Pelloux J, Bellemare-Pelletier A, Gagnon E, Hebert J, Cellot S, Wilhelm BT. Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target. Leukemia. 2016. doi: 10.1038/leu.2016.302. PubMed PMID: 27780967.
• Rouette A, Trofimov A, Haberl D, Boucher G, Lavallee VP, D’Angelo G, Hebert J, Sauvageau G, Lemieux S, Perreault C. Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers. Scientific reports. 2016;6:34019. doi: 10.1038/srep34019. PubMed PMID: 27659694.
• Baruah PS, Beauchemin M, Hebert J, Bertrand R. Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts. PloS one. 2016;11(7):e0159091. doi: 10.1371/journal.pone.0159091. PubMed PMID: 27398719.
• Maiga A, Lemieux S, Pabst C, Lavallee VP, Bouvier M, Sauvageau G, et al. Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets. Blood cancer journal. 2016;6(6):e431. doi: 10.1038/bcj.2016.36. PubMed PMID: 27258612.
• Lavallee VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, et al. Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. Blood. 2016. doi: 10.1182/blood-2016-03-705053. PubMed PMID: 27034432.
• Lavallee VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, et al. RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature. Blood. 2016. doi: 10.1182/blood-2016-03-703868. PubMed PMID: 26968532.
• Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, et al. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. Genes & development. 2016;30(5):508-21. doi: 10.1101/gad.276790.115. PubMed PMID: 26944678.
• Pabst C, Bergeron A, Lavallee VP, Yeh J, Gendron P, Norddahl GL, et al. GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood. 2016. doi: 10.1182/blood-2015-11-683649. PubMed PMID: 26834243.
• Lavallee VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, et al. Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations. Leukemia. 2016. doi: 10.1038/leu.2016.19. PubMed PMID: 26859078. 
• Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Méloche S, Hébert J, Sauvageau G.  The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias. Nature genetics. 2015. PubMed PMID: 26237430.
• Lavallée VP, Gendron P, Lemieux S, D’Angelo G, Hébert J, Sauvageau G. EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations. Blood. 2015 Jan 1;125(1):140-3. Epub 2014 Oct 20.
• Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hebert J, Sauvageau G, Lemieux S, Lecuyer E, Veiga DF, Hoang T. SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells. PLoS genetics. 2014;10(12):e1004768.
• Kleiderman E, Avard D, Besso A, Ali-Khan S, Sauvageau G, Hebert J. Disclosure of incidental findings in cancer genomic research: investigators’ perceptions on obligations and barriers. Clinical genetics. 2015;88(4):320-6. Epub 2014/12/19.2014/12/11. PubMed PMID: 25492269.
• Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood. 2014 Oct 9,124(15):2362-9.
• Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 2014 Jul 3;511(7507):90-3.
• Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J & Sauvageau G. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature Methods. 2014 Apr;11(4):436-42.
• Lehnertz B , Pabst C , Su L , Miller M , Liu F , Yi L , Zhang R , Krosl J , Yung E , Kirschner J , Rosten P , Underhill TM , Jin J , Hébert J , Sauvageau G , Humphries RK , Rossi FM. The methyltransferase G9a regulates HoxA9-dependent transcription in AML.Genes Dev. 2014 Feb 15;28(4):317-27.
• Celton M , Forest A , Gosse G , Lemieux S , Hebert J , Sauvageau G , Wilhelm BT. Epigenetic regulation of GATA2 and its impact in normal karyotype acute myeloid leukemia. Leukemia. 2014 Aug;28(8):1617-26.
• Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA. Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. Blood. 2014 Mar 13;123(11):1720-8.
• Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, Barbour H, Corbeil L, Hébert J, Drobetsky E, Masson JY, Di Noia JM, Affar el B. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.  Proc Natl Acad Sci U S A. 2014, Jan7;111(1):285-90.
• Simard C, Cloutier M, Néron S. Feasibility study: Phosphospecific flow cytometry enabling rapid functional analysis of bone marrow samples from patients with multiple myeloma. Cytometry B Clin Cytom. 2013 Oct 26.
• Giguère A, Hébert J. Identification of a novel fusion gene involving RUNX1 and the antisense strand of the SV2B gene in a BCR-ABL1-positive acute leukemia. Genes, Chromosomes and Cancer. 2013 Dec;52(12):1114-22.
• Tara MacRae, Tobias Sargeant, Sébastien Lemieux, Josée Hébert, Eric Deneault and Guy Sauvageau. RNA-Seq Reveals Spliceosome and Proteasome Genes As Most Stable Transcripts In Human Cancer Cells. PLoS One. 2013 Sep 17;8(9):e72884.
• Nielsen TH, Johnson N, Garnier N, Kwan S, Yao L, Cocolakis E, Hébert J, Morgan RA, Paquet E, Callahan KP, Jordan CT, Assouline S, Miller WH Jr. and Mann KK. Monitoring response and resistance to the novel arsenical darinaparsin in an AML patient. Frontiers in Pharmacology of Anti-Cancer Drugs 2013;4:9.
• Samassekou O., Hébert J., Mai S., Yan J. Nuclear remodeling of telomeres in chronic myeloid leukemia. Genes Chromosomes Cancer. 2013;52(5):495-502.
• Hariri F, Arguello M, Volpon L, Culjkovic-Kraljacic B, Nielsen TH, Hiscott J, Mann KK, Borden KL.The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia. Leukemia. 2013;27(10):2047-55.
• Garnier N, Petruccelli LA, Molina MF, Kourelis M, Kwan S, Diaz Z, Schipper HM, Gupta A, Rincon SD, Mann KK, Miller WH. The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells. Leukemia. 2013;27(11):2220-8.
• Samassekou O, Malina A, Hébert J, Yan J. Presence of alternative lengthening of telomeres associated circular extrachromosome telomere repeats in primary leukemia cells of chronic myeloid leukemia. J Hematol Oncol. 2013;6:26.
• Osborne MJ, Volpon L, Kornblatt JA, Culjkovic-Kraljacic B, Baguet A, Borden KL.
  eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3877-82.
• Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, Hébert J, Ferguson DO, Masson JY, Richard S. The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation. Cell Res. 2012;22(2):305-20.
• Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S. Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation. Cancer Research 2012;72(3):626-35.
• Simon C., Chagraoui J., Krosl J., Gendron P., Wilhelm B., Lemieux S., Boucher G., Chagnon P., Drouin S., Lambert R., Rondeau C., Bilodeau A., Lavallée S., Sauvageau M., Hébert J and Sauvageau G. A Key Role For EZH2 And Associated Genes In Mouse and Human Adult T Cell Acute Leukemia. Genes Dev. 2012;26(7):651-56.
• Herault O, Hope KJ, Deneault E, Mayotte N, Chagraoui J, Wilhelm BT, Cellot S, Sauvageau M, Andrade-Navarro MA, Hébert J, Sauvageau G. A role for GPx3 in activity of normal and leukemia stem cells. J. Exp. Med. 2012;209(5):895-901.
• Charles Vadnais, Sayeh Davoudi, Mojdeh Afshin, Ryoko Harada, Rachel Dudley, Pier-Luc Clermont, Elliot Drobetsky, and Alain Nepveu. CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res. 2012;40(10):4483-95.
• Culjkovic-Kraljacic B, Baguet A, Volpon L, Amri A, Borden KL. The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation. Cell Rep. 2012;2(2):207-15.

2007-2011: BCLQ PUBLICATIONS_2007-2011